Multi-omics approaches to disease
September 16, 2017 – 17:28
High-throughput technologies have revolutionized medical research. The advent of genotyping arrays enabled large-scale genome-wide association studies and methods for examining global transcript levels, which gave rise to the field of “integrative genetics”. Other omics technologies, such as proteomics and metabolomics, are now often incorporated into the everyday methodology of biological researchers. As compared to studies of a single omics type, multi-omics offers the opportunity to understand the flow of information that underlies disease.
Entering the ‘big data’ era in medicinal chemistry
May 15, 2017 – 15:09
Medicinal chemistry is experiencing the advent of the big data era, which biology already entered more than a decade ago, due to the availability of high-throughput genomics technologies. In medicinal chemistry, which is an integral part of drug discovery and traditionally a conservative scientific discipline, big data primarily comprise rapidly increasing numbers of compounds and volumes of associated activity data.
While the practice of medicinal chemistry is just beginning to experience big data phenomena, it is evident that big data will play an increasingly important role going forward. More awareness of big data issues and potential caveats will still need to be raised to positively impact the field.